#Incretin mimetics

GLP-1, GIP, glucagon receptor agonists.

A new review finds heart benefits from incretin drugs like tirzepatide and retatrutide involve pathways beyond blood sugar control.

CT130 is a semaglutide-derived GLP-1 drug tested so far in mice and monkeys, not humans, built around scheduled drug-free intervals.

A 2026 review explains how cell death fuels MASH, the liver disease semaglutide became the first FDA-approved drug to treat.

Semaglutide now has FDA approval for MASH liver fibrosis, and tirzepatide's phase 2 data suggests a stronger signal is coming.

A new review of tirzepatide, semaglutide and related trials raises nutrition questions without proving common clinical malnutrition.

The T-BEAT paper describes a Japanese tirzepatide and oral semaglutide study, but reports baseline data rather than treatment outcomes.

STEP 12 tested semaglutide 2.4 mg in Chinese adults at a BMI of 24 to under 30, a band the earlier STEP obesity trials never enrolled.

A post hoc look at SURPASS-3 MRI finds tirzepatide cut liver fat in type 2 diabetes whether or not patients carried the PNPLA3 I148M gene variant.

A reader on r/peptides asked if peptides could fix years of unexplained weight gain. Here is what GLP-1 drugs actually do, and what to test first.

A matched cohort study links semaglutide and liraglutide use to higher ulcerative colitis remission, though neither drug is approved for IBD.

A new meta-analysis links GLP-1 drugs like semaglutide and tirzepatide to modest erectile-function gains, though other research disagrees.

A new JEADV letter examines whether GLP-1 and GLP-1/GIP drugs like tirzepatide and semaglutide change healthcare use in psoriasis patients.