Explainer
Evidence-led entry points for non-clinicians. What is a GLP-1 receptor agonist, what does ATC A10BX mean, why are some peptides legal in Russia but not the EU.
GLP-1 drugs, PCOS, and trying to conceive
GLP-1 medicines such as semaglutide are not approved to treat PCOS, and current labels require stopping the drug before a planned pregnancy.
STEP 12: semaglutide in Chinese adults
STEP 12 tested semaglutide 2.4 mg in Chinese adults at a BMI of 24 to under 30, a band the earlier STEP obesity trials never enrolled.
Tirzepatide at 6 months: who stays on it
A US claims study of 22,512 tirzepatide starters found 68% still on the drug at six months. Here is what that number does and does not tell you.
Tirzepatide cuts liver fat despite PNPLA3
A post hoc look at SURPASS-3 MRI finds tirzepatide cut liver fat in type 2 diabetes whether or not patients carried the PNPLA3 I148M gene variant.
Tirzepatide and oral health questions
A new oral medicine letter raises an important question about tirzepatide, while the human evidence on oral-health outcomes remains limited.
Can peptides fix a slow metabolism?
A reader on r/peptides asked if peptides could fix years of unexplained weight gain. Here is what GLP-1 drugs actually do, and what to test first.
Can GLP-1 Drugs Help Ulcerative Colitis?
A matched cohort study links semaglutide and liraglutide use to higher ulcerative colitis remission, though neither drug is approved for IBD.
Old retatrutide pen: still safe to use?
Retatrutide is investigational, and even FDA-approved GLP-1 pens must be discarded weeks after first use, not months later.
Orzeyful isn't Ozempic for the brain
The FDA approved oveporexton for narcolepsy in August 2026. It targets the neuropeptide orexin, but the drug itself is not a peptide like semaglutide.
Combining Tesamorelin, Ipamorelin and TRT
A reddit user's heart rate spiked to 151 bpm after combining tesamorelin, ipamorelin and TRT. Here is what the evidence on each actually shows.
Tirzepatide and a rare skin rash: one case
A 2026 case report describes a chest rash clearing during tirzepatide-associated weight loss. Here is what one patient shows, and does not.
Tirzepatide and Prader-Willi diabetes
A 2026 case report describes tirzepatide easing treatment-resistant diabetes in an adult with Prader-Willi syndrome. Here is what one patient shows.