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Daily evidence-led peptide research, regulatory news, expert digest and explainers. Every claim sourced; no AI tells.
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Does the eGFR dip explain heart benefit?
A 376-patient Saudi cohort asked whether the early eGFR change explains heart outcomes on dapagliflozin plus semaglutide. The answer was no.
GLP-1 timing and pregnancy blood pressure
A 2026 meta-analysis of three cohorts found no significant link between GLP-1 use around conception and hypertensive disorders of pregnancy.
Why a peptide vial freezes in the fridge
A fridge that runs too cold can freeze one vial and leave the next one liquid. Here is the physical chemistry, and what a freeze does to a peptide.
Semaglutide meta-analysis: what it adds
A 2026 pooled analysis of four semaglutide trials in non-diabetic obesity lands on almost exactly the number STEP 1 reported in 2021.
GLP-1 and mood drugs: reading the signal
A 2026 Australian study links GLP-1 starts to fewer antidepressant starts. The design behind it decides how much that finding is worth.
Tesamorelin's HIV lipodystrophy evidence
Two 2026 meta-analyses pooled the tesamorelin trials in HIV-associated lipodystrophy. Here is what they found on visceral fat, and where they disagree.
Tirzepatide and pancreatitis: one case
A 2026 case report describes tirzepatide used after recurrent hypertriglyceridemia-mediated pancreatitis. One patient is not evidence of safety.
Japan tirzepatide dispensing and dose mix
Japan's claims data show 86.2% of tirzepatide kits dispensed outside medical institutions, with higher strengths nearly doubling their share in ten months.
Can I buy semaglutide online legally?
Semaglutide is a prescription-only medicine in the US, UK and EU, so buying it online legally means a licensed pharmacy that requires a valid prescription.
Can you drink alcohol on semaglutide?
Semaglutide's label carries no alcohol warning, but it flags gut, blood-sugar and pancreatitis effects that overlap with drinking. Here is the honest read.
Does retatrutide cause muscle loss?
Retatrutide drives large weight loss, and some of it is lean mass. Here is what the one body-composition study and the wider GLP-1 evidence show.
Does semaglutide cause muscle loss?
Semaglutide drives large weight loss, and some of it is lean mass. Here is what the body-composition data and the wider GLP-1 evidence show.