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Daily evidence-led peptide research, regulatory news, expert digest and explainers. Every claim sourced; no AI tells.
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Do other diabetes drugs stop on a GLP-1?
In 3,660 adults starting a GLP-1 or tirzepatide, the count of other glucose-lowering drugs fell for 17.2% of patients and rose for 44.0%.
GLP-1 drugs: how background therapy shifts
A 3,660-patient Polish study found 44% of patients on new incretin-class drugs had more background agents added, 39% saw no change, and 17% had agents removed.
Semaglutide and MASH: what ESSENCE found
Semaglutide has a licensed indication for MASH, the inflamed form of fatty liver disease. Here is what the ESSENCE trial showed, and what it has not.
STEP 12: semaglutide 2.4 mg, Chinese adults
The STEP 12 phase 3b trial tested once-weekly semaglutide 2.4 mg in 242 Chinese adults using Asia-Pacific BMI thresholds. Here is what the data showed.
GLP-1 obesity prescriptions: the fill gap
A 2026 real-world study examines which patient factors predict whether a semaglutide or tirzepatide prescription is actually filled.
Tirzepatide vs carpal tunnel: a 2026 study
A 2026 cohort study found tirzepatide users had lower rates of carpal tunnel syndrome than users of other GLP-1 or anti-obesity drugs.
GLP-1 therapy and IBS: TriNetX findings
In 6,665 matched IBS patients, GLP-1 receptor agonist use was tied to lower coded rates of abdominal pain, bloating, and chronic diarrhoea.
GLP-1 drugs for back pain and knee OA
A 2026 review from UT Health and Johns Hopkins asks whether GLP-1 drugs belong in pain practice for patients with obesity, low back pain, or knee OA.
SELECT trial: semaglutide and dementia risk
A SELECT sub-analysis found semaglutide 2.4 mg slowed a blood-based dementia risk score in 2,970 adults over 65. What the finding shows, and what it does not.
Semaglutide nanoparticles: 2026 HIP study
A 2026 study loaded semaglutide into microfluidic lipid nanoparticles and found a 6-fold permeability gain in intestinal cell models.
Semax and selank with SNRIs and Adderall
No interaction study covers semax or selank alongside SNRIs and Adderall. Here is what the pharmacology shows about the overlapping monoamine and GABA systems.
Tirzepatide: 10-year CVD risk in SURMOUNT-1
Post-hoc SURMOUNT-1 analysis: tirzepatide 15 mg cut predicted 10-year CVD risk by 1.92 pp at 72 weeks, widening to a 5.15 pp gap over placebo at three years.