#Incretin mimetics
GLP-1, GIP, glucagon receptor agonists.
The obesity drug pipeline in 2026
A 2026 JCEM review maps next-generation obesity drugs, from approved dual agonists to triple agonists like retatrutide still in Phase 3.
Hengrui HRS-7535 oral GLP-1: Phase 3 data
Hengrui and Kailera reported Phase 3 results for HRS-7535, an oral GLP-1 drug, in July 2026. Here is what the peer-reviewed Phase 2 data shows.
GLP-1 drugs and US military adherence
A Military Health System study of 10,649 service members found tirzepatide led on adherence and persistence. Male members discontinued more often than females.
GLP-1 Drugs and Menstrual Changes
A 2026 FAERS study found semaglutide and tirzepatide linked to menstrual adverse events in females aged 12-55, adding a new dimension to GLP-1 counseling.
GLP-1 telehealth prescribing oversight
A Yale JAMA secret-shopper study flagged GLP-1 telehealth sites for thin clinical oversight. Here is what peer-reviewed evidence shows about platform quality.
Incretin drugs for T2D: 2026 NMA results
A 2026 network meta-analysis of 102 trials and 98,693 T2D patients ranked tirzepatide first for glycaemic control and retatrutide first for weight loss.
How semaglutide works: the GLP-1 receptor
Semaglutide binds the GLP-1 receptor in the pancreas, brain, and gut. Here is what happens at each site.
GLP-1 drugs and micronutrient risk
How GLP-1 receptor agonists and dual incretin drugs create vitamin and mineral gaps, which nutrients are most at risk, and what monitoring looks like.
Incretins after bariatric surgery
A US cohort of 208,155 post-bariatric patients: tirzepatide beat semaglutide on weight loss (17.2% vs 12.0%). No significant cardiovascular signal either way.
Bofanglutide vs semaglutide in Chinese T2D
Ann Intern Med Phase 2b: bofanglutide 18 mg biweekly cut HbA1c by 2.28 points versus 1.60 for semaglutide 1 mg weekly in Chinese patients with type 2 diabetes.
GLP-1 drugs in Medicaid: the coverage gap
Most US Medicaid programs restrict or exclude GLP-1 obesity drugs. Here is what the research says about who gets access and why coverage varies by state.
Tirzepatide and steatotic liver disease
A 2026 real-world study finds tirzepatide cut major liver complications and mortality in adults with steatotic liver disease and cardiometabolic dysfunction.