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#GLP-1 class

Coverage of the GLP-1 receptor agonist family and its successors.

Trial readouts

Tirzepatide and MASLD in Mice

A mouse and cell study linked tirzepatide with less liver fat and inflammation, with Dectin-1 signaling proposed as part of the mechanism.

10 Oct 2026 · PeptideMethods Editorial Team · 5 min read
Trial readouts

GLP-1 safety cohort: what it found

A 2026 South Korean cohort linked semaglutide and liraglutide initiation with selected safety outcomes, without proving causation.

9 Oct 2026 · PeptideMethods Editorial Team · 5 min read
Trial readouts

Personalising Tirzepatide Maintenance

A Lancet letter raises the maintenance question. SURMOUNT-MAINTAIN supports continued tirzepatide but does not supply an individual dosing formula.

9 Oct 2026 · PeptideMethods Editorial Team · 5 min read
Trial readouts

Semaglutide equity model explained

A 25-year semaglutide model weighed cost per QALY against projected equity for older adults with obesity and cardiovascular disease.

9 Oct 2026 · PeptideMethods Editorial Team · 5 min read
Trial readouts

Tirzepatide During ECT: One Case

One patient taking tirzepatide completed 17 ECT sessions without complications, but the case report cannot establish a safe protocol.

9 Oct 2026 · PeptideMethods Editorial Team · 5 min read
Trial readouts

Tirzepatide and Migraine: Two Cases

Two patients reported fewer migraine days on tirzepatide, but weight loss and an uncontrolled design prevent causal conclusions.

9 Oct 2026 · PeptideMethods Editorial Team · 5 min read
Trial readouts

Tirzepatide Ocular Study: What We Know

A letter on tirzepatide ocular outcomes has no public abstract. The underlying cohort found associations, not proof of eye protection.

9 Oct 2026 · PeptideMethods Editorial Team · 5 min read
Trial readouts

Vutiglabridin and Semaglutide in Mice

A preclinical mouse study found more fat loss with vutiglabridin plus semaglutide, but it provides no evidence of human efficacy.

9 Oct 2026 · PeptideMethods Editorial Team · 5 min read
Explainer

HD1916 trial: chemically made semaglutide

A Phase III trial found HD1916 met its prespecified equivalence criterion against reference semaglutide for weight change at 44 weeks.

8 Oct 2026 · PeptideMethods Editorial Team · 5 min read
Explainer

Tirzepatide and oral symptoms

A 2026 paper describes reported oral and salivary symptoms with incretin medicines, but it does not establish causation for tirzepatide.

8 Oct 2026 · PeptideMethods Editorial Team · 4 min read
Trial readouts

Tirzepatide vs SGLT2 Drugs in MASLD

A matched MASLD cohort linked tirzepatide to fewer deaths and liver events than SGLT2 inhibitors, but it cannot prove superiority.

8 Oct 2026 · PeptideMethods Editorial Team · 5 min read
Trial readouts

GIP Agonists and Blockers in Obesity

A 2026 review asks why GIP receptor agonists and blockers can both support weight loss, then separates mouse mechanisms from human trial evidence.

7 Oct 2026 · PeptideMethods Editorial Team · 5 min read