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#For patients

Written for adults considering a peptide as part of their health management.

Explainer

Orforglipron vs oral semaglutide in T2D

ACHIEVE-3 put the orforglipron pill head to head with the oral semaglutide pill in type 2 diabetes. Orforglipron won on HbA1c and lost on tolerability.

23 Sept 2026 · PeptideMethods Editorial Team · 5 min read
Explainer

Semaglutide access and health inequity

Semaglutide works. Access does not follow need. Here is what fill-rate, pricing and policy data show about who actually gets treated, and who does not.

23 Sept 2026 · PeptideMethods Editorial Team · 5 min read
Explainer

Semaglutide and wet AMD: signal vs proof

A 2026 study flagged semaglutide among five drugs with raised wet AMD reporting. Here is what that kind of signal can and cannot tell you.

23 Sept 2026 · PeptideMethods Editorial Team · 4 min read
Explainer

What is food noise? Five theories

A 2026 Appetite review says food noise still has no settled definition. Here are the five theories behind it, and what the GLP-1 survey data shows.

23 Sept 2026 · PeptideMethods Editorial Team · 5 min read
Explainer

BPC-157 for a running injury: evidence

A runner's forum question reflects real interest in BPC-157, but animal studies and anecdotes do not establish safe or effective injury treatment.

22 Sept 2026 · PeptideMethods Editorial Team · 4 min read
Explainer

Retatrutide and gut-health claims

A podcast discussion can raise useful questions, but phase 2 retatrutide evidence does not make it an approved general tool for gut health.

22 Sept 2026 · PeptideMethods Editorial Team · 4 min read
Explainer

STEP UP semaglutide muscle findings

A small STEP UP MRI subgroup found lower thigh fat infiltration and lower measured muscle volume, with sit-to-stand repetitions preserved.

22 Sept 2026 · PeptideMethods Editorial Team · 4 min read
Trial readouts

What 49 Online GLP-1 Prescribers Required

A secret-shopper study found rapid access to GLP-1 prescriptions across 49 US websites, often without direct clinician-patient communication.

21 Sept 2026 · PeptideMethods Editorial Team · 5 min read
Explainer

Tirzepatide, GLP-1 Drugs, and Gum Disease

A large propensity-matched study links tirzepatide to lower periodontal disease risk than other GLP-1 drugs in type 2 diabetes.

21 Sept 2026 · PeptideMethods Editorial Team · 5 min read
Explainer

MASLD Screening Without a Liver Biopsy

A new review explains how FIB-4 screens for MASLD and MASH in primary care, now that semaglutide and resmetirom can treat confirmed cases.

19 Sept 2026 · PeptideMethods Editorial Team · 4 min read
Explainer

What Patients Want in an Obesity Drug

A US survey of 800 adults finds route of administration and weight-loss efficacy outweigh simpler dosing rules when picking an obesity medication.

19 Sept 2026 · PeptideMethods Editorial Team · 4 min read
Explainer

Ozempic Face: What the Research Says

Researchers reviewed 23 resources on GLP-1 drugs and facial volume loss. A peer response says the evidence for a distinct semaglutide effect is weak.

19 Sept 2026 · PeptideMethods Editorial Team · 4 min read