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#For patients

Written for adults considering a peptide as part of their health management.

Explainer

How Tesamorelin works: the mechanism

Tesamorelin binds GHRH receptors in the pituitary, triggers GH pulses, and raises IGF-1. Plain-English guide to the mechanism.

7 Jul 2026 · PeptideMethods Editorial Team · 4 min read
Explainer

Tesamorelin side effects and safety data

The FDA label and phase-3 trials list injection site reactions, arthralgia, edema, and a threefold rise in new-onset dysglycemia. Here is what the data show.

7 Jul 2026 · PeptideMethods Editorial Team · 4 min read
Country deep-dive

What tirzepatide costs in Germany

Cash prices, GKV reimbursement rules, PKV coverage, and the AMNOG process that determines what Mounjaro costs in Germany in 2026.

7 Jul 2026 · PeptideMethods Editorial Team · 7 min read
Explainer

What is Semax? A plain-English explainer

Semax is a synthetic neuropeptide licensed in Russia for stroke recovery and unapproved in the EU, UK, and US. Here is what the research actually shows.

6 Jul 2026 · PeptideMethods Editorial Team · 3 min read
Explainer

Semaglutide side effects: what trials show

The STEP and SUSTAIN programmes documented semaglutide adverse events at scale. Here is what the data show, from GI effects to the thyroid boxed warning.

5 Jul 2026 · PeptideMethods Editorial Team · 4 min read
Explainer

What is Semaglutide?

Semaglutide (Ozempic, Wegovy, Rybelsus) is a GLP-1 receptor agonist for type 2 diabetes and weight management. How it works and what the trials show.

5 Jul 2026 · PeptideMethods Editorial Team · 4 min read
Explainer

Semaglutide in schizophrenia: HISTORI trial

Three randomised trials show semaglutide cuts weight and blood sugar in antipsychotic-treated patients without worsening psychiatric symptoms.

2 Jul 2026 · PeptideMethods Editorial Team · 5 min read
Explainer

What is PT-141? A plain-English explainer

PT-141 (bremelanotide, brand name Vyleesi) is a melanocortin receptor agonist with one FDA-approved indication and no EU marketing authorisation.

30 Jun 2026 · PeptideMethods Editorial Team · 4 min read
Explainer

Retatrutide: a plain-English explainer

Retatrutide is an investigational triple-receptor agonist: GLP-1, GIP, and glucagon. Phase 2 data showed up to 24% weight loss at 48 weeks. Not approved.

30 Jun 2026 · PeptideMethods Editorial Team · 4 min read
Explainer

Semaglutide and weight in schizophrenia

A 24-week trial found semaglutide reduced body weight by 9.8% in people with schizophrenia on clozapine or olanzapine, with partial regain after stopping.

30 Jun 2026 · PeptideMethods Editorial Team · 4 min read
Explainer

Semaglutide and the cost of CV benefit

A 2026 cost-effectiveness review places semaglutide, a GLP-1 agonist, in the moderate tier for preventing cardiovascular events. Here is what that means.

25 Jun 2026 · PeptideMethods Editorial Team · 3 min read
Explainer

Semaglutide and heart risk: a 2026 review

A 2026 meta-analysis of 11 trials found semaglutide cut major cardiovascular events by about a third, similarly in people with and without diabetes.

25 Jun 2026 · PeptideMethods Editorial Team · 4 min read